Mehmet Esen was born in Istanbul in 1958. Mehmet Esen, who was influenced by Münir Özkul, whom he watched on stage, and whose one-man play he staged and exhibited at Cihangir Primary School, continued his interest in theater while studying at Ankara High School. During his student years, he received training at the Ankara Deneme Sahnesi (Ankara Experimental Stage), became a member of the cast at the same place, and starred in his first play, Bozkır Dirliği (Steppe Resilience), with his classmate Altan Erkekli. Although his goal in those years was to join AST, he entered the Revolutionary Ankara Art Theater (DAST) through Erkan Yücel, whom he crossed paths with at Küçük Sahne and whom he later described as "one of the most important actors in the world, a master, a human being". During the DAST process, he was subjected to torture, detention and bad behavior. After a while, they formed the Ankara People's Theater with the money they earned by working in construction sites, but with the guidance of Haldun Taner; he moved to Istanbul. He worked under the direction of Münir Özkul. On September 12, he was arrested and imprisoned for 11 months. The artist, who had serious health problems and underwent heart surgery, played in the Dostlar Theater after meeting Genco Erkal, whom he called "my master". He was extremely affected by the death of Erkan Yücel and took a break from art for 4 years. Then, in 1986, he returned to the cinema and had film experiences. With the support of the then governor of Izmir, Nevzat Ayaz, he broke the passport ban and traveled to Germany and joined the formation of Tiyatrom. He achieved great success when the artist Kerim Afşar gave him the lead role in the play Criminals and Criminals, and he traveled to European countries to perform the play. In 1990, he started to improvise in his plays and attracted great interest. In addition to acting, he was also working on screenplays. Mehmet Esen married Julia, a psychiatrist, in 1991 and had a child from this marriage. In 1997, he went to Germany again and did theater studies at Theater Forum (Berlin). He also acted in Levent Kırca theater for a while. He continues to work on a novel, cinema projects and theater works as an actor and director.