When Melis Mutluç was only three and a half years old, she attracted all the attention by reciting the 10 verses of the National Anthem in front of 50 thousand people at the Tekirdağ Cherry Festival. After this, Melis Mutluç was enrolled in an agency by her father Nebi Mutluç and starred in the TV series Yol Arkadaşım in 2008.

Melis Mutluç, who received great acclaim for her acting and dubbing in her first series, took part in two episodes of the series Bu Kalp Seni Unutur mu? in 2009 after the end of Yol Arkadaşım. In 2010, she starred in the series Friday Kalsa. She played the role of Mihrimah Sultan in the Magnificent Century. Finally, she played the childhood of the character played by Beren Saat in the movie My World. He received great acclaim and attention with his acting. Lastly, he played the character named Yâren in the series Aramızda Kalsın.